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Coordination bonds often exhibit pH sensitivity, allowing supramolecular nanomedicines to remain stable in the blood but dissociate in the acidic tumor microenvironment (TME), thereby achieving targeted drug release [34]

The ratio of GSH to GSSG decreases under stress conditions

The key areas are IGF-1, glucose handling, lipids, thyroid context, and fluid-retention symptoms

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Figure 2 Both insoluble fibrils and soluble A oligomers exert potent neurotoxicity by forming plaques and triggering pathological cascades, including synaptic failure, excitotoxicity, changes in membrane permeability, and chronic inflammation (77, 78)

77 Thus, the KD could regulate dysregulated brain metabolism, mitochondrial homeostasis, and inflammation in AD