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It stimulates follicle enlargement, supports scalp vascularization through VEGF, and extends the anagen growth phase

It also acts as a direct precursor to the neurotransmitter acetylcholine

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In saliva, but not in serum, various polyphenols, and the microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone were exclusively present as unconjugated molecules ( 6.3 Site-specific metabolism: blood cells The observation of a facilitated uptake of 5-(3,4-dihydroxyphenyl)--valerolactone into blood cells and its determination in cell samples of osteoarthritis patients after intake of Pycnogenol (see section 5.2 Distribution into blood cells) prompted systematic advances to elucidate the detailed metabolism of 5-(3,4-dihydroxyphenyl)--valerolactone in human blood cells ( ( 7 Elimination The major excretion routes of dietary polyphenols and their metabolites include renal and biliary elimination of compounds circulating in blood

and decreased concentrations of IL-12 and interferon gamma in the bronchoalveolar lavage (177)

Shilpa: Liposomes 101 is worth a read