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Some health issues can change how much B12 is needed

Because the list of potential differentialsincluding renal carcinoma, cholangiocarcinoma, mesenteric carcinoma, and ovarian carcinomawas broad, it was important to choose a chemotherapeutic protocol with activity across multiple carcinoma types, consistent with CUP treatment principles

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Specialized stable versions designed for oral use offer better survival through the gastrointestinal tract

However, prolonged use of a year or more combined with reduced dietary intake could gradually deplete these stores

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