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The elevated synthesis of ketone bodies is exacerbated in states of excessive acetyl-CoA synthesis from fatty acids

To help illustrate the therapeutic significance and developmental advancement of these natural chemicals, Table 2 highlights their molecular targets, experimental models used, clinical status, and potential future research avenues

While changes in the endometabolome, or intracellular metabolites, may be reflected to some extent in the exometabolome, this is not always the case

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Thus, the extent and specificity of tN myelination remain largely unknown, leaving open critical questions about how selective and region-appropriate myelination can be achieved in diverse transplant scenarios