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Benefits were more pronounced in studies using 6001,200mg per day over at least eight weeks.2 A 2022 randomized controlled trial in patients with metabolic syndrome found that 600mg of ALA daily for 12 weeks significantly reduced triglyceride levels and total cholesterol compared to placebo.59 However, the study did not observe significant changes in LDL-C or HDL-C

This unique behaviour of glycated proteins also explains the strong clinical correlation between chronic hyperglycemia and susceptibility to neurodegenerative disorders

Drug Dev Res

Most adverse effects were mild or moderate, no serious adverse effects were reported in the Sativex -treated subjects, and there were no withdrawals due to adverse events

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

Disruptions in this axis, driven by gut dysbiosis, have been implicated in the pathogenesis of a wide range of neurodegenerative and neuropsychiatric disorders