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Glutathione reduces cellular aging and disease risk by neutralizing reactive oxygen species (ROS) and free radicals, preventing lipid peroxidation, protein denaturation, and DNA oxidative damage

This review argues that future research should integrate molecular, circuit, and behavioral perspectives, with emphasis on cell-typespecific receptor dynamics, adaptive plasticity under different nicotine exposure conditions, and individual genetic risk factors

Acknowledgments The authors would like to thank the barn staff at IRTA-Facilities, for taking care of the animal management and its support during sampling

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