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This review summarizes how epigenetic mechanisms, such as DNA methylation, histone modifications, non-coding RNAs and RNA modifications, convey the enduring effects of addictive drugs on gene expression related to mood regulation, stress response, and neural plasticity, offering potential biomarkers for early detection and individualized treatment

doi: 10.1016/j.bbadis.2013.04.009 108 PastorinoJ

This paper discusses the cytokine storm syndrome observed in COVID-19 patients in brief and emphasizes on some natural immunosuppressant agents derived from plants sources that can play an important role in targeting and mitigation of the cytokine storm observed in COVID-19

Adrenal overactivation in response to chronic gut inflammation produces a flattened diurnal cortisol curve with characteristic early afternoon collapse

These modifications increase resistance to IGF-1 binding proteins, enhancing stability and prolonged activity in controlled research environments

Oxidative Stress Oxidative and nitrosative stress are thought to play an important role in the development of vitiligo [9]