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Recently it was shown that GRX1-roGFP1-iE is still oxidized to more than 90% when expressed in the ER of HeLa cells (Birk et al., Stable expression of GRX1-roGFP2-iL and GRX1-roGFP2 in the cytosol of homozygous rml1 plants allowed ratiometric measurements of the yet undefined E GSH with both sensors

Sappl PG, Carroll AJ, Clifton R, Lister R, Whelan J, Harvey Millar A, et al

In HD patient-derived cells, a downregulation of DNA repair genes ( APEX1 , BRCA1 , RPA1 , and RPA3 ), which are involved in mismatch and loop-out repair pathways was observed

These hallmarks are interconnected and tightly related to spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress