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Furthermore, transcriptomic analysis was performed on the final HLCs to explore the molecular basis underlying the differences observed between the two differentiation methods

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Although the G-CAN panel agreed with some of the recommendations in whole or in part, there are some fundamental issues the panel concluded to be flaws in the ACP clinical practice guideline, specifically concerning the lack of clear advice about ULT for patients with recurrent flares, ULT for patients with tophi, and serum urate level monitoring for patients on ULT