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Hematoxylin and eosin (HE), safranin O-fast green, and immunohistochemistry staining against Matrix Metalloproteinase 13(MMP13) (AF5355, 1:100, Affinity, Jiangsu, China), Collagen II(COLII) (AF0135, 1:100, Affinity, Jiangsu, China)and Aggrecan (DF7561, 1:100, Affinity, Jiangsu, China) were performed

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