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Adrenal adenomas are the most prevalent adrenal tumor type and are typically nonfunctional, meaning they do not produce excessive hormones ( 3.4 Adrenal steroidogenesis The pathophysiology of lethal adrenal disorders is heavily influenced by oxidative stress, and mutations in antioxidant defense genes can have a considerable impact on adrenal steroidogenesis

The distinct role of HIF-1 and HIF-2 in hypoxia and angiogenesis

62,63 While the exact basis for this paradoxical role remains unclear, excessive ROS levels induced by these drugs may underlie their inhibitory effects (Fig

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Diagnostic applications have most prominently benefited from advancements in molecular characterization

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