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Prolonged use of Vitamin B6 (over 2 months) at high doses exceeding 1g/day can lead to severe peripheral neuropathy, with symptoms including unsteady gait and numbness in the hands and feet

Most of us can prevent vitamin B12 deficiency by consuming enough of it in the foods we eat

Safety and Side Effects of Methylcobalamin and Adenosylcobalamin Side Effects and Safety Common Side Effects (mild to moderate) : Mild headache Nausea or upset stomach Skin rash or itching Rare Side Effects (moderate to severe) : Anxiety or nervousness Chest pain or shortness of breath Hypersensitivity reactions (e.g., swelling, severe rash) Safety Summary : Methylcobalamin is generally well-tolerated when taken as directed

doi:10.1152/ ajpgi.00268

Certain cations of the invention may be prepared via the two-step process outlined inScheme2, as exemplified with the preparation of cation 1f

10.3934/bioeng.2021012 41 GuimeraA