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Chem Sci 8:33903398

PMID: 90 TianYGaoXYangXChenSRenY

In COPD, YTHDF1 facilitates the translation of IREB2 (Iron-responsive element-binding protein 2), consequently inducing ferroptosis [58]

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Once outside the cell, glutathione (GSH) degradation occurs exclusively in the extracellular space, and only on the surface of cells that express the ectoenzyme -glutamyl transferase

Their low bioavailability, short half-life in the body, and complex metabolic conversion make it difficult to achieve effective therapeutic concentrations ( in vivo even when concentrations are extremely low, facilitating a more precise evaluation of their bioavailability ( Current reviews mainly focus on the impacts of particular subclasses of flavonoids or their effects within particular disease contexts, while a holistic perspective is absent