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Therefore, the cystine/glutamate antiporter (system x c ), which consists of two subunits including SLC7A11 and SLC3A2 and is responsible for the import of cysteine, the raw material for GSH synthesis, as well as the associated substrates and enzymes responsible for GSH synthesis, are equally important targets for ferroptosis [10]

5.2 JUXTAPID REMS Program Because of the risk of hepatotoxicity associated with JUXTAPID therapy, JUXTAPID is available through a restricted program under the REMS

All cell lines were authenticated through STR profiling by the Cell Bank or ATCC

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15, 585594 10.1016/j.cmet.2012.04.002 [DOI] [PubMed] [Google Scholar] 55.Hu, W., Xu, R., Zhang, G., Jin, J., Szulc, Z.M., Bielawski, J.et al

Structural modification of the coumarin ring system yields derivatives with enhanced target selectivity and improved metabolic stability in select compounds