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A plaques result from the abnormal cleavage of amyloid precursor protein (APP) by betasecretase (BACE1) and gammasecretase, leading to the aggregation of A peptides, particularly A42, which is highly toxic to neurons (Hardy and Selkoe 2002)

It's typically diagnosed through a complete blood count (CBC) and peripheral blood smear, which reveals the enlarged red blood cells

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In the majority of these studies, one or more EAATs were transiently or permanently genetically eliminated and the effects on brain function examined

Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory pept1-mediated tripeptide KPV in a murine model

Yet, clinical data are scarce and many of these peptides remain under active scientific investigation