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About 510% of Caucasians are PM, presenting a metabolic deficiency in CYP2D6 activity (Sachse et al., 1997)

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in a clinical trial at the Royal Victoria Hospital in Montreal in 1980-1981 12

MTTP gene transcription is positively regulated by PPAR and increased MTTP expression is paralleled by a change in apoB100 secretion, but a paradoxical decrease in circulating triglycerides in mice [116]