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(2016) demonstrated that colonic transit time is related to bacterial metabolism and mucosal turnover, with prolonged colonic transit time associated with increased protein fermentation and decreased carbohydrate fermentation

High glucose and diabetes modulate cellular proteasome function: implications in the pathogenesis of diabetes complications

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In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

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