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Patients with pre-existing depression or anxiety should have mental health monitoring during orforglipron therapy, and any new mood symptoms should be reported promptly

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While these treatments help thousands of patients find relief, the initial post-injection period can sometimes feel counterintuitive: you came in seeking pain relief, but now your knee hurts more than before

Updated 2/9/2021

2026 guide

The most important column is the last onethere is no evidence from randomized trials in humans that any of these peptides provide the benefits that are advocated