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Sxc inhibition with erastin leads to a type of iron-mediated cell death called ferroptosis, a process that has also been suggested to occur and impair islet viability during transplantation [11]

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The prooxidant potential of carotenoids becomes more favorable in the face of increasing oxygen partial pressure (pO) and/or increasing carotenoid concentrations in tissues, resulting in more favorable conditions for autooxidation that leads to the formation of carotenoid alkoxyl/peroxyl radicals

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