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H-CMS NSs eradicate excessive ROS and exhibit CAT-like activity, thereby polarizing macrophages toward an anti-inflammatory phenotype and promoting infected tissue healing

When there is a prolonged increase in oxygen reactive species (ROS) levels that the existing antioxidant potential cannot eliminate, cell enters in the state of chronic oxidative stress

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Interestingly, the lower concentration of glutathione, 1mM increased cell adhesion compared to control (Figure 5A)