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A single-blinded human trial assessing the combination of vitamin C (1 g) and vitamin E (400 mg) in healthy adults showed the combination of the two vitamins improved Interlukin-1 and tumor necrosis factor- (TNF-) levels and reduced lipopolysaccharide-induced prostaglandin E2 production, suggesting an enhanced immune response (50)

Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: A drug dose dependent study

Dang X, He B, Ning Q, Liu Y, Guo J, Niu G, Chen M

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There is a lack of long-term data beyond 23 months, and large-scale, randomized controlled trials are limited, according to Anetta Reszko, MD, a board-certified dermatologist and dermatologic surgeon, a clinical assistant professor of dermatology at Weill Cornell Medical College