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Human PAD4 regulates histone arginine methylation levels via demethylimination

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B: However, in the endothelial cells with high level of phosphor AKT, following the block of VEGF stimulation, the AKT pathway remains active inducing transcription of FGF, an angiogenic factor, which on one side promotes endothelium proliferation and on the other further phosphorylates AKT producing a positive loop

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doi: 10.1186/s12951-022-01395-9 160 ZhangBSuXKangJChenL

High amounts of homocysteine have also been linked to neural tube defects in early pregnancy