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doi: 10.1016/j.femsre.2005.04.013 26 HinesM

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CD38 is also one of the three ectoenzymes in the CD38/CD203a/CD73 pathway that produces ADO, which not only regulates immune response in hypoxic conditions but also suppresses the antitumor immune response by recruiting MDSCs and Treg cells, inhibiting the activity of T effector cells and thus favoring tumor progression

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Studies on osteoblastic cell behavior showed that Tb4 promotes both adhesion and proliferation of osteoblasts through focal adhesion signaling and ERK1/2 activation