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The biodistribution of NP4 was studied by using ICP-MS

IGF-1 LR3 features 20-30 hour half-life, minimal IGFBP binding, strong systemic whole-body effects, and once-daily dosing

doi: 10.3389/fimmu.2025.1740644 Received 06 November 2025 Revised 29 December 2025 Accepted 29 December 2025 Published 14 January 2026 Volume 16 - 2025 Edited by Zong Sheng Guo, University at Buffalo, United States Reviewed by Chi-Heng Wu, Dren Bio, Inc., United States Xingxing Yuan, Heilongjiang University of Chinese Medicine, China Updates Copyright 2026 Fan, Guo, Li, Wang, Bao, He and Jin