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A genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma

Results: B7h4 was highly expressed in ~60% of iCCAs, mainly cold tumors

Single-agent inhibition is unlikely to provide durable benefit in controlling advanced disease 17 and recent studies report CB-839 synergizes with -lapachone in PDAC 55 and BCL-2 inhibition in acute myeloid leukaemia 31

Early initiation of treatment after the onset of vision loss and a longer treatment duration appears to be associated with better odds of improving or stabilising vision