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Materials and methods Cell culture LUHMES cells (CRL-2927, American Type Culture Collection) were used in all in vitro experiments, as previously published by our group [9, 10]

Its sold both as a cosmetic ingredient and as a research compound, and after an April 2026 FDA Federal Register notice it moved into the second wave of the agencys compounding (PCAC) review, with a decision expected before February 2027

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There is a paucity in the literature of papers addressing molecular mechanisms of new peptide polyagonists and extending these to preclinical and clinical data

Dihexa is sold strictly for in vitro laboratory research

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