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doi:10.1007/BF01971753 Schneider-Helmert D, Schoenenberger GA

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Semaglutide, a modified GLP-1 (glucagon-like peptide-1) analog with extended half-life, provides complementary mechanisms including glucose-dependent insulin secretion, appetite regulation through hypothalamic pathways, and additional gastric emptying modulation

This result is in agreement with a previous in vitro study

Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon-like peptide-1/glucagon receptor agonist SAR425899 in comparison with liraglutide