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Further refinements in conditioning plus precise graft composition and additional cellular therapy are emerging as techniques to personalize the approach to HSCT for each patient Introduction The first allogeneic hematopoietic stem cell transplants (HSCTs) were carried out in patients with X-linked severe combined immunodeficiency (SCID) and Wiskott Aldrich syndrome (WAS) in 1968 ( This article will review some of the new approaches in order to achieve the goals of transplant: to limit graft failure and graft versus host disease (GVHD), limit short and long-term toxicity, promote long-term good immune reconstitution and quality of life

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