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5.2.4 Promotes iron-mediated autophagy Wang et al

& Tan, J

Glyoxalase I (EC 4.4.1.5) catalyzes the conversion of methylglyoxal and reduced glutathione to S -D-lactoylglutathione

Sensitivity to one substance may lead to cross-sensitization to another substance

OS activates different transcription factors (e.g., NF-B) that induce the expression of pro-inflammatory cytokines, adhesion molecules and chemokines [73]

In addition, equol improves IVM in porcine oocytes by activating the Nrf2/KEAP1 antioxidant pathway, decreasing ROS levels, and increasing the expression of haem oxygenase (HO-1), catalase(CAT), glutathione peroxidase 1 (GPX1) and SOD, and attenuating OS [111]