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Accordingly, the unique genomic map of SARS-CoV-2 virus and the extent of its mediated virushost proteinprotein interactions that trigger human metabolic reprogramming and dysregulation (HMRD) in favor of the virus life cycle, defines the ultimate severity and fate of COVID-19 23,24,25,26

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This uncertainty creates a precautionary gap- both regulators and manufacturers may be cautious, delaying product approvals until more safety data are available

10.1016/j.toxlet.2014.04.011 54 LiS.TanH.-Y.WangN.ZhangZ.-J.LaoL.WongC.-W.et al (2015)

These four small G proteins bind to GTP/GDP and exhibit GTP hydrolase activity