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Description

The failure of the antioxidant system to negate the pathological rise in the oxidative species is exacerbated by reduction in levels of the major cellular nucleophile, GSH due to their covalent modification by dopamine quinone species 20,43,44,45

NAC increases the cellular levels of antioxidants and reduces glutathione at higher doses

At a concentration of 25M BSO, there was a 12.3-fold decrease in the amount of total glutathione compared to the control

Interestingly, stabilization of O-GlcNAcylation increased the number of Ezh2 and Ezh2/OGT target genes and EZH2 O-GlcNAcylation plays a role in EZH2 recruitment to the promoter of defined HCC-relevant direct target genes