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R., Mardaryev, A

Previous work using neuronal cell lines (N2A and NSC-34) suggested that SOD1 aggregate uptake is mediated by fluid phase endocytosis 27,28

GLUT1, the rate-limiting glucose transporter in M1 macrophages, exhibits increased expression that contributes to ROS production and pro-inflammatory mediator expression (68)

Ethics statement The study protocol complies with the ethical guidelines of the 1975 Declaration of Helsinki, and in agreement with national regulation on observational studies, it was notified and approved by the local ethics committee (number: 46430/03.08.2020) and the need for patient's informed consent was waived

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In conjunction with the increased metabolic demand for energy during exercise, there is increased blood flow to the exercising muscles [1]