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Individuals of African descent tend to have 23 times higher Lp(a) levels than those of European descent

Another observation quite unexplained, is the finding that in dogs, after 5 years of hyperglycemia, pericyte loss and capillary dropout occurs in retinal capillaries but not in brain (178): there appears to be a specific retinal cause for diabetic retinopathy, although the two tissues have the same neuroectodermal origin

NPJ Biofilms Microbiomes 8, 102

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Insulin resistance is a risk factor for dementia [7], cognitive deterioration later in life in those with type 2 diabetes mellitus (T2DM), and mood disorder, such as depression [8,9] as well as cognitive dysfunction in youth [10]