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Additionally, inhibitors of Ang-2 expression by pericytes could prevent the destabilization of the Ang-1-TIE2 system and subsequent detachment and migration of pericytes into the intervascular space.Citation 64 This could be accomplished by the downregulation of the genes responsible for the production of Ang-2.Citation 38 Of note in streptozotocin-induced diabetic mouse models, the pericyte bridging phenomenon, discussed previously, occurs prior to the reduction in total number of pericytes found in retinal vasculature and was reversible through the exogenous administration of insulin.Citation 47 Given that this microvascular finding may serve as one of the first definitive signs of the impending downstream pathology seen in DR, treatment at this stage in the disease course may represent a key intervention point during the NPDR phase in order to prevent subsequent irreversible damage to retinal vasculature

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