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This paradox may be explained by enzymatic dysfunction rather than transcriptional downregulation

Indeed, while efficiently inducing ferroptosis in different tumor cell lines, RSL3 and ML162 were found to also acts on TXRND1, an important detoxifying enzyme whose inhibition can also trigger apoptosis and/or ferroptosis [51, 52]

PMC 7904969

Not as a drug or natural health product

Functional Effects Observed in Preclinical Models In preclinical research models, GHK-Cu has been studied for its effects on cellular growth markers, extracellular matrix protein expression, and oxidative stress indicators

PMID: 20460639