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These findings are consistent with our previous metabolomic study of sertraline, another SSRI, in depressed patients 35 , where perturbations in TRP, in particular, changes in methoxyindole pathway and the ratio of KYN/TRP were correlated with treatment outcomes

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Key unresolved questionsincluding the exact temporal sequence and causal relationship between NTFs signaling dysfunction and mitochondrial impairment in human PD, the existence of an irreversible threshold beyond which intervention is ineffective, and the universal applicability of preclinical findings to sporadic PDmust be addressed through rigorous, human-relevant research

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Low vitamin D levels may intensify PCOS symptoms, including insulin resistance, ovulatory, menstrual irregularities, infertility, hyperandrogenism, and obesity