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This is a convention that recurs across such protocols, not a specification derived from a controlled trial: no controlled human study has examined or validated this specific ratio

Ibutamoren mimics ghrelin at the GHS-R1a receptor, increasing growth hormone pulsatility in both amplitude and frequency, which enhances the downstream anabolic effects of IGF-1. Garcia et al., Endocrinology 2

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Mechanism and Application In vitro tests show that Ipamorelin mimics natural ghrelin, binding straight to the growth hormone secretagogue receptor (GHSR)