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These include: (i) low sensitivity in the early stage of LB (11 to 55%), leading to numerous false negatives, (ii) the occurrence of false positives due to cross-reactivity with other bacterial and viral species, (iii) the impact of antibiotic treatment on the hosts antibody response, and (iv) the complexity of the diagnostic process, which is time-consuming, requires skilled operators, and often involves subjective interpretation 1,2,3

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Glutathione and adaptive immune responses 17

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