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Certain regulatory genes have been identified in animal models to drive gonads descent: insulin-like 3 (INSL3), laxin/insulin-like family peptide receptor 2 (LGRF8), anti-Mllerian hormone (AMH), and HOX gene family [93]

proteolytic cleavages will depend on the nature of protein folding and the nature of proteases either in the cytoplasm or in the proteasome

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N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity