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The spaceflight analog and ground, based studies have produced important findings concerning the mechanisms and reasons for gut microbial dysbiosis in extreme conditions

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In addition to a lack of high-quality evidence of benefit in RLS sufferers, benzodiazepines have well-known side effects that limit their use, including daytime sedation, cognitive impairment, instability and falls, tolerance and dependence, depression, and respiratory failure, particularly in older adults (Walters 2024)

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Commonly reported effects include: These effects vary by individual and should be monitored by a healthcare provider