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14 While most patients do not mind mild choreiform movements as a trade-off for good mobility, troublesome dyskinesias should be addressed with strategies aimed at reducing the amount of L-dopa at each dose, as mentioned above, including fractioning L-dopa into smaller but more frequent dosages

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In terms of fatty acid oxidation, PTEN promoter hypermethylation activates the mTORC1 signaling pathway, triggering a dual metabolic shift: both inhibiting the expression of carnitine palmitoyltransferase 1 A (CPT1A) and inhibiting mitochondrial -oxidation

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