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It is most often used on the forehead, around the eyes (crows feet) and between the brows

Age Ageing 33 , 3441 (2004)

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Combo synergy Vascular convergence, tissue divergence Complementarity hinges on a single principle: BPC-157 initiates local repair, TB-500 amplifies systemic regeneration

This systemic mechanism is part of why TB-500 is sometimes considered for injuries that involve more diffuse tissue involvement or chronic, widespread inflammation rather than a single discrete injury site