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Each year, 5 to 35 out of every 100,000 people are diagnosed with PD, and its global prevalence for 2050 has been projected to reach 230 to 320 cases per 100,000 [1, 2]

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This quick signal is rapidly degraded by the protein DPP-4 (dipeptidyl peptidase 4)

While more severe forms are not all that common, some research estimates that MCAS could affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]

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Recently, a multifunctional dopamine coating method has been developed, which only needs to immerse the substrate in alkaline dopamine solution [53]