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Long-acting muscarinic antagonists (LAMAs), such as tiotropium and aclidinium, reduce acetylcholine-mediated bronchoconstriction and suppress mucus hypersecretion by inhibiting goblet cell and submucosal gland activity [78, 79]

Furthermore, it can eliminate ROS, reduce the levels of malondialdehyde (MDA), protein carbonyls, thiols, and nitrotyrosines, and stimulate the activities of SOD and catalase

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probiotics have been shown to lower the serum levels of Antinuclear Antibodies (ANA) ( Furthermore, vitamin D also showed significant inhibition of NF-B pathways (181), and a regulatory effect regarding cytokine production, thus it inhibits proinflammatory cytokines in SLE pathogenesis, including IFN-, IL-17, IL-23, IL-6, and TNF- (182184), while stimulating anti-inflammatory cytokine production like IL-10 and TGF- (185, 186)

This change is consistent with the observed increase of RT-deletion with Berberine-VQ-N 3 (NMe 2 ), showing that strengthened G4 formation underlies the higher berberine binding (Fig