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iii) changes in intracellular homeostasis through certain paracrine mechanisms (20)

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It has been observed using in vitro cell culture studies that the nascent amyloid is nontoxic but aged amyloid becomes toxic to neurons [110]

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doi: 10.3389/fphar.2022.854674 Received 14 January 2022 Accepted 07 February 2022 Published 03 March 2022 Volume 13 - 2022 Edited by Francisco Javier Cubero, Complutense University of Madrid, Spain Reviewed by Hyeong-Geug Kim, Indiana University, United States Xiu Zhou, Wuyi University, China Updates Copyright 2022 Zhang and Feng