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162 Furthermore, S1PR inhibits extrathymic and innate Treg cell production while driving Th1 development in a reciprocal manner, which is reciprocally regulated by S1P1-mTOR and the opposing TGF--Smad3 signaling

and the Open Fund Project of the Yunnan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease Prevention and Treatment (YPKLS2025-007, YPKLS2024-006, 2019DG016)

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