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4-HNEs are involved in the MAPK-dependent signal pathways of cellular stress response, particularly by facilitation of the phosphorylation of JNK and p38, which results in their activation [122]

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The target of rapamycin (mTOR) also regulates mitophagy and controls autophagy by regulating the activity of the ULK1 complex

4 Zhang JY, Fabricant PD, Ishmael CR, Wang JC, Petrigliano FA, Jones KJ

Multidrug resistance-associated proteins: expression and function in the central nervous system

Indian J Exp Biol 42(4):389397 Russo A, Borrelli F, Campisi A, Acquaviva R, Raciti G, Vanella A (2003) Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera