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2.1.2.1 Affinity-driven modularity: streptavidinbiotin as a universal adapter The streptavidinbiotin system leverages ultrahigh affinity (dissociation constant, Kd 4 10 14 M) to enable non-covalent yet exceptionally stable antigen display (Figure 1B

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This route was specifically chosen to ensure continuous and direct access of MT-II to the central nervous system, thereby maximizing its potential therapeutic effects

This developmental disruption may result in compromised intracranial volume, thereby imposing spatial constraints on normal brain expansion and maturation [113]