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Notably, red wine polyphenol extract has been shown to efficiently suppress the inflammation of intestinal epithelial cells by inhibiting JAK/STAT and promoting Nrf2 pathways (116)

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Further studies of the PNPLA3 polymorphism in the context of NASH in humans and its mechanism of action are required, to confirm whether murine models with this genetic mutation are good preclinical models of NASH

This study identifies aspartate as one such limiting metabolite, and suggests that its availability could be targeted for anti-cancer therapies. Birsoy is a former postdoc in professor of biology David Sabatinis lab, who authored a paper published in the same issue of Nature Cell Biology , identifying aspartate as a major growth limitation in oxygen-deprived tumors