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When skin expands or shrinks rapidly, collagen and elastin the main proteins that make up the structure of our skin can break apart

Body compositional changes and changes in laboratory values Body compositional changes and changes in laboratory values between the PG-DTR and TG groups are illustrated in Fig

The extracellular microenvironmental pH is 7.4 (basic) in normal tissue which is altered in the cancer microenvironment to 6.8 (acidic), favoring the activity of various metalloproteinases, activating several signal transduction pathways and acting as a chemical barrier for many anticancer drugs that exuberate malignancy and tumor aggression [198,199,200,201,202,203]

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